منابع مشابه
Perioperative myocardial ischemia reperfusion injury.
Myocardial I-R injury contributes to adverse cardiovascular outcomes after cardiac surgery. The pathogenesis of I-R injury is complex and involves the activation, coordination, and amplification of several systemic and local proinflammatory pathways (Fig. 4). Treatment and prevention of perioperative morbidity associated with myocardial I-R will ultimately require a multifocal approach. Combini...
متن کاملMyocardial ischemia, reperfusion and free radical injury.
Reperfusion of coronary arteries to limit myocardial ischemic injury and extent of myocardial necrosis is possible by either the use of fibrinolytic therapy, coronary angioplasty or coronary artery bypass surgery. The concept that early reperfusion may salvage jeopardized myocardium is derived from basic experimental studies which purported to demonstrate that the ultimate extent of irreversibl...
متن کاملCell Autophagy and Myocardial Ischemia/Reperfusion Injury
Ischemic heart disease is a clinical syndrome resulting from myocardial ischemia and is characterized by an imbalance between the supply and demand of myocardial blood flow and myocardial oxygen metabolism. It is currently one of the major diseases that endanger human health. Early and effective reconstruction of ischemic myocardial blood perfusion is the fundamental measure taken to prevent th...
متن کاملPlatelets, diabetes and myocardial ischemia/reperfusion injury
Mechanisms underlying the pathogenesis of ischemia/reperfusion injury are particularly complex, multifactorial and highly interconnected. A complex and entangled interaction is also emerging between platelet function, antiplatelet drugs, coronary diseases and ischemia/reperfusion injury, especially in diabetic conditions. Here we briefly summarize features of antiplatelet therapy in type 2 diab...
متن کاملCurcumin attenuates myocardial ischemia–reperfusion injury
Background Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world. Methods Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated. Results and Conclusions The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery...
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ژورنال
عنوان ژورنال: Seminars in Cardiothoracic and Vascular Anesthesia
سال: 2012
ISSN: 1089-2532,1940-5596
DOI: 10.1177/1089253211436350