Myeloperoxidase and singlet oxygen: a reappraisal

Formation of singlet oxygen by the myeloperoxidase-mediated antimicrobial system.

Myeloperoxidase. H,O,, and a halide form a potent antimicrobial system which is operative in the polymorphonuclear leukocyte (PMN). The formation of singlet oxygen (‘0,) by this system is suggested by (a) the conversion of 2,5diphenylfuran to its specific singlet oxygen product cisdibenzoylethylene (cis-DBE); (b) the inhibition of this reaction by the ‘0, quenchers p-carotene, bilirubin, histid...

Singlet Oxygen

Singlet oxygen (O2) is a higher energy state molecular oxygen species. It is one of the most active intermediates involved in chemical and biochemical reactions. To fully appreciate the reactivity of O2, it is necessary to understand its physical and chemical nature. This paper reviews the generation, quenching and detection of O2. Its properties, possible chemical reactions are presented as we...

A Mems Singlet Oxygen Generator

The design, creation, and demonstration of a singlet oxygen generator (SOG) that operates on the microscale are presented. The micro singlet oxygen generator (μSOG) chip creates singlet delta oxygen (O2(Δ)) in an array of packed bed reaction channels fed by inlets with pressure drop channels to equalize flow. An integrated capillary array separates the liquid and gas byproducts, and microscale ...

Singlet Oxygen Trapping Porphyrins

Fiber-optic Singlet Oxygen

Traditionally, Type II heterogeneous photo-oxidations produce singlet oxygen via external irradiation of a sensitizer and external supply of ground-state oxygen. A potential improvement is reported here. A hollow-core fiber-optic device was developed with an ‘‘internal’’ supply of light and flowing oxygen, and a porous photosensitizer-end capped configuration. Singlet oxygen was delivered throu...