Myelin Repair: From Animal Models to Humans

ABCA1 and Inflammation: From Animal Models to Humans.

Helicobacter pylori infection and disease: from humans to animal models.

Informative and tractable animal models that are colonized by well-defined microbial pathogens represent ideal systems for the study of complex human diseases. Helicobacter pylori colonization of the stomach is a strong risk factor for peptic ulceration and distal gastric cancer. However, gastritis has no adverse consequences for most hosts and emerging evidence suggests that H. pylori prevalen...

Acetaminophen-induced Liver Injury: from Animal Models to Humans

Drug-induced liver injury is an important clinical problem and a challenge for drug development. Whereas progress in understanding rare and unpredictable (idiosyncratic) drug hepatotoxicity is severely hampered by the lack of relevant animal models, enormous insight has been gained in the area of predictable hepatotoxins, in particular acetaminophen-induced liver injury, from a broad range of e...

From Humans to Animals: Animal Models in Schizophrenia

Schizophrenia is one of the most devastating psychiatric disorders. Schizophrenia affects 1.1% of the population or 51 million people (NIMH). Schizophrenia is a disorder that affects multiple brain regions and systems. Symptoms include positive symptoms, negative symptoms and cognitive deficits. Much research has focused on two neurotransmitter systems, dopamine and glutamate. Postmortem studie...

Nanomedicine for tuberculosis: Insights from animal models

Patient noncompliance to current tuberculosis (TB) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant TB. To avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. Other potential advantages of the system include the possibility of selec...