Mycophenolate mofetil for systemic lupus erythematosus refractory to other immunosuppressive agents
نویسندگان
چکیده
منابع مشابه
Mycophenolate mofetil for systemic lupus erythematosus refractory to other immunosuppressive agents.
BACKGROUND Mycophenolate mofetil (MMF) is an immunosuppressive drug widely used in solid organ transplantation, and it may play an increasing role in autoimmune disease. MMF has been introduced as a novel immunosuppressive agent in systemic lupus erythematosus (SLE), often in patients intolerant of or resistant to conventional immunosuppressive regimens. METHODS We studied 21 patients with SL...
متن کاملMycophenolate mofetil in neuropsychiatric systemic lupus erythematosus.
Neuropsychiatric abnormalities frequently occur in patients with systemic lupus erythematosus, affecting as many as 14-75% of people with this disease. High-dose steroid with or without anticoagulation is the mainstay of treatment in neuropsychiatric systemic lupus erythematosus (NPSLE). Use of mycophenolate as a steroid sparing drug may be a potential alternative agent in the therapy of NPLE, ...
متن کاملSkin manifestations of systemic lupus erythematosus refractory to multiple treatment modalities: poor results with mycophenolate mofetil.
OBJECTIVE Skin disease can be one of the most refractory clinical manifestations of systemic lupus erythematosus (SLE). The standard therapy consists of sunscreens, topical corticosteroids and antimalarials. However in difficult cases a variety of other drugs have been tried. Here we describe our clinical experience with mycophenolate mofetil (MMF) in patients with cutaneous manifestations of S...
متن کاملMycophenolate mofetil in the treatment of systemic lupus erythematosus.
PURPOSE OF REVIEW Clinicians are increasingly using mycophenolate mofetil (MMF) for the treatment of systemic lupus erythematosus (SLE). This review will discuss the key studies that have contributed to our understanding of the efficacy and safety of MMF in the treatment of SLE. RECENT FINDINGS The Aspreva Lupus Management Study (ALMS) firmly established that MMF is equivalent to intravenous ...
متن کاملSuccessful Treatment of Refractory Thrombocytopenia with Mycophenolate Mofetil in a Patient with Systemic Lupus Erythematosus
While mild thrombocytopenia in systemic lupus erythematosus (SLE) is frequently seen in the context of active disease, severe thrombocytopenia causing significant bleeding is not that common. Corticosteroids are considered the first line therapy for severe thrombocytopenia in SLE. Second-line therapeutic agents or splenectomy have been reported to be effective for patients who fail to respond t...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2002
ISSN: 1460-2172
DOI: 10.1093/rheumatology/41.8.876