Mutual relations between the amygdala and pro-inflammatory cytokines: IL-1β and IL-6

Interleukin 1 (IL-1) and interleukin 6 (IL-6) are typical examples of multifunctional pro-inflammatory cytokines involved in the regulation immune response, hematopoiesis, inflammation. Both peripheral intraventricular administration these causes acute phase symptoms, e.g. fever, activation hypothalamic-pituitary-adrenal axis psychological depression. The amygdala belongs to structures limbic system response. Increased activity may lead changes role amygdala, medial prefrontal cortex, anterior cingulate cortex or insula. aim study was present mutual interactions between such as 1β (IL-1 beta) (IL-6). Most data included this review comes from animal studies.