Mutations inDNMT3A and loss of RKIP are independent events in acute monocytic leukemia
نویسندگان
چکیده
منابع مشابه
Mutations inDNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
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متن کاملAcute monocytic leukemia
Keywords Disease name and synonyms Definition Differential diagnosis Etiology Clinical presentation Diagnostic methods Epidemiology Management including treatment Outcome Unresolved questions and conclusion References Abstract Acute myeloblastic leukemia (AML) is a group of malignant bone marrow neoplasms of myeloid precursors of white blood cells. Acute monocytic leukemia (AML-M5) is one of th...
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Background and Objective: Identification of cytogenetic and molecular changes plays an important role in acute myeloid leukemia (AML) patients. Thus, they are used in classification, prognosis and treatment of the disease. The CD123 expression and FLT3 gene mutations are also the variations that may assist in prognosis and treatment of patients with AML.Methods:</...
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PURPOSE Activating Notch-1 mutations are frequent in T-cell acute lymphoblastic leukemia (T-ALL), occurring in >50% of patients. In murine models of T-ALL, Notch-1 activation can both directly initiate leukemia and cooperate secondarily to other primary events. Whether acquisition of Notch-1 mutations is an early initiating event or a secondary event in the pathogenesis of human T-ALL is unclea...
متن کاملDetection of R882 Mutations in DNMT3A Gene in Acute Myeloid Leukemia: A Method Comparison Study
Background: Somatic mutations in the hotspot region of the DNA-methyltransferase 3A (DNMT3A) gene were recurrently identified in acute myeloid leukemia (AML). It is believed that DNMT3A mutations confer an adverse prognosis for AML patients. These lines of evidence support the need for a rapid and cost-efficient method for the detection of these mutations. The present study aimed to establish h...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2012
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2012.068429