Mutation analysis of the candidate genes SCN1B-4B, FHL1, and LMNA in patients with arrhythmogenic right ventricular cardiomyopathy
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چکیده
منابع مشابه
Mutation analysis of the candidate genes SCN1B-4B, FHL1, and LMNA in patients with arrhythmogenic right ventricular cardiomyopathy
INTRODUCTION Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically determined heart disease characterized by fibrofatty infiltrations in the myocardium, right and/or left ventricular involvement, and ventricular tachyarrhythmias. Although ten genes have been associated with ARVC, only about 40% of the patients have an identifiable disease-causing mutation. In the present study...
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Arrythmogenic right ventricular (RV) cardiomyopathy (ARVC) is a cardiomyopathy characterized pathologically by fibrofatty replacement primarily of the RV and clinically by life-threatening ventricular arrhythmias in apparently healthy young people. The prevalence of the disease has been estimated at 1 in 5,000 individuals, although this estimate will likely increase as awareness of the conditio...
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1. Konstam, M. Heart failure training. J Am Coll Cardiol 2004;44: 1361–2. 2. Naccarelli GV. Does it make sense to train plumbers as electricians? J Am Coll Cardiol 2004;44:1358–60. 3. McAlister FA, Steward S, Ferrua S, McMurray JJJ. Multidisciplinary strategies for the management of heart failure patients at high risk for admission. A systematic review of randomized trials. J Am Coll Cardiol 20...
متن کاملArrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia1
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is characterized by the patchy replacement of myocardium by fatty or fibrofatty tissue. These changes lead to structural abnormalities including right ventricular enlargement and wall motion abnormalities that can be detected by echocardiography, angiography, and cine MRI. ARVC/D is a genetically heterogeneous disorder, since it...
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ژورنال
عنوان ژورنال: Applied & Translational Genomics
سال: 2012
ISSN: 2212-0661
DOI: 10.1016/j.atg.2012.06.001