Musica Britannica 100

Biography of Wilhelm Ostwald for Encyclopaedia Britannica

Tax Britannica: Nineteenth Century Tariffs and British National Income∗

The literature on British economic history presumes that Britain was a free trader after the repeal of the Corn Laws and that her tariff levels were thus below those which were optimal for maximizing utility. Presumably, if the optimal British tariff had been positive and greater than the levels established by mid-century, a reduction to zero of all tariffs that remained would have lowered Brit...

Acylated flavonol glycosides from the flower of Inula britannica.

Three new acylated flavonol glycosides, patuletin 7-O-(6' '-isobutyryl)glucoside (1), patuletin 7-O-[6' '-(2-methylbutyryl)]glucoside (2), and patuletin 7-O-(6' '-isovaleryl)glucoside (3), were isolated from the n-BuOH extract of Inula britannica flowers by bioassay-guided fractionation, together with other known flavonoids. The structures were elucidated by 1D and 2D NMR, FABMS, and other spec...

Secondary metabolites from Inula britannica L. and their biological activities.

Inula britannica L., family Asteraceae, is used in traditional Chinese and Kampo Medicines for various diseases. Flowers or the aerial parts are a rich source of secondary metabolites. These consist mainly of terpenoids (sesquiterpene lactones and dimmers, diterpenes and triterpenoids) and flavonoids. The isolated compounds have shown diverse biological activities: anticancer, antioxidant, anti...

Methotrexate Dosage Reduction Upon Adalimumab Initiation: Clinical and Ultrasonographic Outcomes from the Randomized Noninferiority MUSICA Trial.

OBJECTIVE To examine the clinical and ultrasonographic (US) outcomes of reducing methotrexate (MTX) dosage upon initiating adalimumab (ADA) in MTX-inadequate responders with moderately to severely active rheumatoid arthritis (RA). METHODS MUSICA (NCT01185288) was a double-blind, randomized, parallel-arm study of 309 patients with RA receiving MTX ≥ 15 mg/week for ≥ 12 weeks before screening. ...