Murine Tim-1 is excluded from the immunological synapse
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Murine Tim-1 is excluded from the immunological synapse
The interaction between T cells and APCs bearing cognate antigen results in the formation of an immunological synapse (IS). During this process, many receptors and signaling proteins segregate to regions proximal to the synapse. This protein movement is thought to influence T cell function. However, some proteins are transported away from the IS, which is controlled in part by ERM family protei...
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The immunological synapse (IS) has proved to be a stimulating concept, particularly in provoking discussion on the similarity of intercellular communication controlling disparate biological processes. Recent studies have clarified some of the underlying molecular mechanisms and functions of the IS. For both T cells and natural killer (NK) cells, assembly of the IS can be described in stages wit...
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ژورنال
عنوان ژورنال: F1000Research
سال: 2012
ISSN: 2046-1402
DOI: 10.12688/f1000research.1-10.v1