Murine Middle Ear Inflammation and Ion Homeostasis Gene Expression
نویسندگان
چکیده
منابع مشابه
Mouse Middle Ear Ion Homeostasis Channels and Intercellular Junctions
HYPOTHESIS The middle ear contains homeostatic mechanisms that control the movement of ions and fluids similar to those present in the inner ear, and are altered during inflammation. BACKGROUND The normal middle ear cavity is fluid-free and air-filled to allow for effective sound transmission. Within the inner ear, the regulation of fluid and ion movement is essential for normal auditory and ...
متن کاملInner ear tissue remodeling and ion homeostasis gene alteration in murine chronic otitis media.
HYPOTHESIS Studies were designed to ascertain the impact of chronic middle ear infection on the numerous ion and water channels, transporters, and tissue remodeling genes in the inner and middle ear. BACKGROUND Permanent sensorineural hearing loss is a significant problem resulting from chronic middle ear disease, although the inner ear processes involved are poorly defined. Maintaining a bal...
متن کاملDexamethasone modulation of MUC5AC and MUC2 gene expression in a generalized model of middle ear inflammation.
OBJECTIVES/HYPOTHESIS To examine the effect of dexamethasone on basal and proinflammatory cytokine-induced gel-forming mucin expression in human middle ear epithelial cell line (HMEEC-1). METHODS HMEEC-1 was exposed to proinflammatory cytokines, tumor necrosis factor-alpha (TNF-), and interleukin-1 beta (IL-1β) to identify optimal mucin induction. The HMEEC-1 was incubated with dexamethasone ...
متن کاملControl of Middle Ear Inflammatory and Ion Homeostasis Genes by Transtympanic Glucocorticoid and Mineralocorticoid Treatments
HYPOTHESIS Transtympanic steroid treatment will induce changes in ion homeostasis and inflammatory gene expression to decrease middle ear inflammation due to bacterial inoculation. BACKGROUND Otitis media is common, but treatment options are limited to systemic antibiotic therapy or surgical intervention. Systemic glucocorticoid treatment of mice decreases inflammation and improves fluid clea...
متن کاملInner ear disturbances related to middle ear inflammation
The inner and middle ear are connected mainly through round and oval windows, and inflammation in the middle ear cavity can spread into the inner ear, which might induce a disturbance. In cases with intractable otitis media, attention should also be paid to symptoms related to the inner ear. In this paper, middle ear inflammation and related inner ear disturbances are reviewed with a focus on r...
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ژورنال
عنوان ژورنال: Otology & Neurotology
سال: 2011
ISSN: 1531-7129
DOI: 10.1097/mao.0b013e31820e6de4