Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits
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Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits
INTRODUCTION Transgenic overexpression of amyloid precursor protein (APP) genes that are either entirely human in sequence or have humanized Aβ sequences can produce Alzheimer-type amyloidosis in mice, provided the transgenes also encode mutations linked to familial Alzheimer's Disease (FAD). Although transgenic mice have been produced that overexpress wild-type mouse APP, no mice have been gen...
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ژورنال
عنوان ژورنال: Acta Neuropathologica Communications
سال: 2015
ISSN: 2051-5960
DOI: 10.1186/s40478-015-0252-9