Multivariate Curve Resolution and Carbon Balance Constraint to Unravel FTIR Spectra from Fed-Batch Fermentation Samples
نویسندگان
چکیده
منابع مشابه
Multivariate Curve Resolution and Carbon Balance Constraint to Unravel FTIR Spectra from Fed-Batch Fermentation Samples
The current work investigates the capability of a tailored multivariate curve resolution-alternating least squares (MCR-ALS) algorithm to analyse glucose, phosphate, ammonium and acetate dynamics simultaneously in an E. coli BL21 fed-batch fermentation. The high-cell-density (HCDC) process is monitored by ex situ online attenuated total reflection (ATR) Fourier transform infrared (FTIR) spectro...
متن کاملModelling of a Fed-Batch Fermentation Process
This report describes the building of a simulator for prediction of the dissolved oxygen concentration, the oxygen transfer rate and the concentration of carbon dioxide in a fermentation process. The steady state models were made using the linguistic equations method. The dynamic models were made using Simulink ® toolbox in the Matlab ® . At the beginning, some basics about fermentation and mic...
متن کاملBatch-to-Batch Iterative Learning Control of a Fed-batch Fermentation Process Using Incrementally Updated Models
Batch-to-batch iterative learning control of a fed-batch fermentation process using batchwise linearised models identified from process operation data is presented in this paper. Due to model-plant mismatches and the present of unknown disturbances, off-line calculated control policy may not be optimal when implemented to the real process. The repetitive nature of batch process allows informati...
متن کاملOptimization of fed-batch Saccharomyces cerevisiae fermentation using dynamic flux balance models.
We developed a dynamic flux balance model for fed-batch Saccharomyces cerevisiae fermentation that couples a detailed steady-state description of primary carbon metabolism with dynamic mass balances on key extracellular species. Model-based dynamic optimization is performed to determine fed-batch operating policies that maximize ethanol productivity and/or ethanol yield on glucose. The initial ...
متن کاملFuzzy modeling and control of a fed-batch fermentation
The goal of this paper is to propose an alternative to classical control methods of a fed-batch fermentation. Fuzzy modeling and control theory is used for that purpose. The fuzzy supervisor based on human experience and experimental data, is designed to compute the set values for a PI controller which controls the feeding dilute flow to the fermentator. The results are compared with those obta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioengineering
سال: 2017
ISSN: 2306-5354
DOI: 10.3390/bioengineering4010009