Multivalent Polyanionic 2D Nanosheets Functionalized Nanofibrous Stem Cell?based Neural Scaffolds

Because developed neural cells are no longer regenerative and proliferative, achieving regenerations by using induced pluripotent stem (IPS cells) for nerve diseases have recently attracted much attention. Since the IPS cells’ growth differentiation can be manipulated different physical chemicals cues, scaffolds combining beneficial nanostructures extracellular matrix may become an ideal interface to promote differentiation. In this work, a biocompatible multivalent polyanion, hyperbranched polyglycerol sulfate, is used modify graphene oxide obtain bio-adhesive 2D nanosheets. After coating electrospinning nanofibers, nanosheets-functionalized nanofibrous applied mediate proliferation, lineage specification, of cells. The results suggest that modified improve adhesion proliferation combined with high efficiency in maintaining their stemness. During process, maturity, meanwhile decreasing specification toward astrocyte. Overall, study not only provides new multivalent/bio-adhesive integrate chemical cues facilitate targeted but also presents novel pathway fabrication carbon nanomaterials-based biocomposites therapies.