Multitude of ion channels in regulation of transmitter release
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چکیده
منابع مشابه
Modulation of transmitter release via presynaptic ligand-gated ion channels.
Neurons communicate through the exocytotic release of transmitters from presynaptic axon terminals and the ensuing activation of postsynaptic receptors. Instantaneous responses of postsynaptic cells to released neurotransmitters are mediated by ligand-gated ion channels, whereas G protein-coupled receptors mediate rather delayed effects. Moreover, the actions of ionotropic receptors are transie...
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Introduction Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. There are multiple receptors for glutamate: in addition to the fast transfer of information via the recently cloned receptors for AMPA [(RS)-y-amino-3hydroxy5 -methyl-4-isoxazolepropionate]/kainate [ l ] and the high-affinity kainate receptor [2], Ca+ influx via the post-synaptic N-methyl-i>...
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The primary function of the presynaptic nerve terminal is to release transmitter quanta and thus activate the postsynaptic target cell. In almost every step leading to the release of transmitter quanta, there is a substantial involvement of ion channels. In this review, the multitude of ion channels in the presynaptic terminal are surveyed. There are at least 12 different major categories of io...
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Rami Rahamimoff* and Julio M. Fernandez† et al., 1993; Jonas et al.,1993; Bekkers, 1994; Von Kitzing et al., 1994; Edwards, 1995; Bekkers and Stevens, 1995). *Department of Physiology and the BernardKatz Minerva Centre for Cell Biophysics After the discovery that nerve terminals contain vesicles (Palade, 1954; Robertson, 1956), it was proposed that Hebrew University-Hadassah Medical School Jeru...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences
سال: 1999
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.1999.0379