Multiscale modelling in biomechanics

Multiscale modelling in biomechanics

Multiscale modelling and team science: the future of orthopaedic biomechanics

Introduction Some of the most exciting developments in recent biomechanics research regard topics that lay at boundaries: boundaries between dimensional scales (i.e. cell-tissue interaction), between sub-systems (i.e. cardiovascular and musculoskeletal), or between different domains of biomedical knowledge (i.e. biology and engineering). This is a trend that we are observing in the entire biome...

Multiscale modeling methods in biomechanics

More and more frequently, computational biomechanics deals with problems where the portion of physical reality to be modeled spans over such a large range of spatial and temporal dimensions, that it is impossible to represent it as a single space-time continuum. We are forced to consider multiple space-time continua, each representing the phenomenon of interest at a characteristic space-time sc...

Physical modelling in biomechanics.

Physical models, like mathematical models, are useful tools in biomechanical research. Physical models enable investigators to explore parameter space in a way that is not possible using a comparative approach with living organisms: parameters can be varied one at a time to measure the performance consequences of each, while values and combinations not found in nature can be tested. Experiments...

Multiscale cartilage biomechanics: technical challenges in realizing a high-throughput modelling and simulation workflow.

Understanding the mechanical environment of articular cartilage and chondrocytes is of the utmost importance in evaluating tissue damage which is often related to failure of the fibre architecture and mechanical injury to the cells. This knowledge also has significant implications for understanding the mechanobiological response in healthy and diseased cartilage and can drive the development of...