Multiscale modeling of twitch contractions in cardiac trabeculae
نویسندگان
چکیده
منابع مشابه
Effects of gadolinium on twitch force and triggered propagated contractions in rat cardiac trabeculae.
UNLABELLED We have recently described that local contractions can be triggered by a preceding twitch in rat cardiac trabeculae in or near damaged ends of the muscle. These local contractions appeared to propagate along the trabeculae with a constant velocity; hence, they can be denoted as triggered propagated contractions (TPCs). These studies have also shown that stretch and/or subsequent shor...
متن کاملSpontaneous and propagated contractions in rat cardiac trabeculae
Sarcomere length measurement by microscopic and laser diffraction techniques in trabeculae of rat heart, superfused with Krebs-Henseleit solution at 21 degrees C, showed spontaneous local sarcomere shortening after electrically stimulated twitches. The contractions originated in a region of several hundred micrometers throughout the width of the muscle close to the end of the preparation that w...
متن کاملRole of the sarcolemma in triggered propagated contractions in rat cardiac trabeculae.
We have recently described that after contractions propagate through multicellular cardiac muscle preparations. These propagating contractions are triggered in damaged regions of rat right ventricular trabeculae during relaxation of electrically stimulated twitches. Propagation of triggered contractions has been attributed to calcium ions that diffuse along the preparation, causing calcium-indu...
متن کاملStretch and quick release of rat cardiac trabeculae accelerates Ca2+ waves and triggered propagated contractions.
Rapid shortening of active cardiac muscle [quick release (QR)] dissociates Ca2+ from myofilaments. We studied, using muscle stretches and QR, whether Ca2+ dissociation affects triggered propagated contractions (TPCs) and Ca2+ waves. The intracellular Ca2+ concentration was measured by a SIT camera in right ventricular trabeculae dissected from rat hearts loaded with fura 2 salt, force was measu...
متن کاملSpontaneous contractions in rat cardiac trabeculae. Trigger mechanism and propagation velocity
It has previously been observed that spontaneous contractions start in a region of damage of isolated right ventricular trabeculae of rat, propagate along the muscle, and induce triggered arrhythmias (Mulder, B.J.M., P.P. de Tombe, and H.E.D.J. ter Keurs. 1989. J. Gen. Physiol. 93:943-961). The present study was designed to analyze the mechanisms that lead to triggered propagated contractions (...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2021
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.202012604