Multipoint maximum likelihood mapping in a full-sib family of an outbreeding species
نویسندگان
چکیده
منابع مشابه
Maximum likelihood mapping of quantitative trait loci using full-sib families.
A maximum likelihood method is presented for the detection of quantitative trait loci (QTL) using flanking markers in full-sib families. This method incorporates a random component for common family effects due to additional QTL or the environment. Simulated data have been used to investigate this method. With a fixed total number of full sibs power of detection decreased substantially with dec...
متن کامل3FunMap: full-sib family functional mapping of dynamic traits
MOTIVATION Functional mapping that embeds the developmental mechanisms of complex traits shows great power to study the dynamic pattern of genetic effects triggered by individual quantitative trait loci (QTLs). A full-sib family, produced by crossing two heterozygous parents, is characteristic of uncertainties about cross-type at a locus and linkage phase between different loci. Integrating fun...
متن کاملOn the use of linear regression and maximum likelihood for QTL mapping in half-sib designs.
Methods of identification of quantitative trait loci (QTL) using a half-sib design are generally based on least-squares or maximum likelihood approaches. These methods differ in the genetical model considered and in the information used. Despite these differences, the power of the two methods in a daughter design in very similar. Using an analogy with a one-way analysis of variance, we propose ...
متن کاملFunctional Mapping Model of Quantitative Trait Loci in a Full-sib Family
Functional mapping of quantitative trait loci (QTL) has embedded the biological mechanisms and processes of dynamic traits in the statistical method of QTL mapping. Although the statistical model for functional mapping has been well developed in inbred lines, it has not been proposed in a full-sib family, in which the number of alleles may vary over loci and the linkage phases are usually unkno...
متن کاملMaximum likelihood estimation of linkage disequilibrium in half-sib families.
Maximum likelihood methods for the estimation of linkage disequilibrium between biallelic DNA-markers in half-sib families (half-sib method) are developed for single and multifamily situations. Monte Carlo computer simulations were carried out for a variety of scenarios regarding sire genotypes, linkage disequilibrium, recombination fraction, family size, and number of families. A double hetero...
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ژورنال
عنوان ژورنال: Genetics Research
سال: 2011
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672311000279