Multiplex Analysis of Urinary Cytokine Levels in Rat Model of Cyclophosphamide-induced Cystitis
نویسندگان
چکیده
منابع مشابه
Effect of Lycopene on Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats
Background: Cylophosphamide is used alone or in combination with other drugs for treatment of neoplastic diseases. Hemorrhagic cystitis is a major potential toxicity and dose limiting side effect of cyclophosphamide. The aim of this study was to evaluate the effects of lycopene compared with some antioxidants for the prevention of cyclophosphamide induced hemorrhagic cystitis in rats. Methods: ...
متن کاملChanges in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis.
Cyclophosphamide (CYP)-induced cystitis alters micturition function and produces reorganization of the micturition reflex. This reorganization may involve cytokine expression in the urinary bladder. These studies have determined candidate cytokines in the bladder that may contribute to the reorganization process. An RNase protection assay was used to measure changes in rat bladder cytokine mRNA...
متن کاملRole of p75 in female rat urinary bladder with cyclophosphamide- induced cystitis
Klinger MB, Vizzard MA. Role of p75 in female rat urinary bladder with cyclophosphamide-induced cystitis. Am J Physiol Renal Physiol 295: F1778–F1789, 2008. First published October 8, 2008; doi:10.1152/ajprenal.90501.2008.—Previous studies demonstrated changes in urinary bladder neurotrophin content and upregulation of neurotrophin receptors, TrkA and the p75 neurotrophin receptor (p75), in mic...
متن کاملExpression of Caveolin-1 in Rat Urinary Bladder with Cyclophosphamide-Induced Cystitis
PURPOSE The purposes of this study were to investigate the effect of cyclophosphamide (CYP)-induced inflammatory cystitis on caveolin 1 in rat urinary bladder and to determine the role of these molecules in the bladder dysfunction that occurs in inflammatory change in rat urinary bladder. METHODS Female Sprague-Dawley rats were divided into control (n=30) and experimental (n=30) groups. Cysti...
متن کاملExpression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis.
Chemokines, otherwise known as chemotactic cytokines, are proinflammatory mediators of the immune response and have been implicated in altered sensory processing, hyperalgesia, and central sensitization following tissue injury or inflammation. To address the role of CXCL12/CXCR4 signaling in normal micturition and inflammation-induced bladder hyperreflexia, bladder inflammation in adult female ...
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ژورنال
عنوان ژورنال: Urology
سال: 2009
ISSN: 0090-4295
DOI: 10.1016/j.urology.2008.07.031