Multiple myeloma and frequency of synchronous and second primary malignancies

Malignancies accompanying multiple myeloma (MM) can be observed at diagnosis or during the course of disease. Several trials have investigated type, frequency, and effects these malignancies on overall survival MM patients. Here, we aimed to investigate frequency types previous/synchronous second primary malignancies, median duration develop a malignancy course, effect in our Three hundred ten symptomatic patients were included analyzed retrospectively. detected before after recorded. The SPSS 26.0 (NY, USA) software program was used for statistical analysis, p-value below 0.05 considered significant. Eight (2.5%) 5 (1.6%) had previously/synchronous respectively. Chronic lymphocytic leukemia, prostate cancer, breast metastatic endometrial cancer most common previous synchronized (0.3%, 1%, 0.6%, 0.3%, respectively). During follow-up, stomach, larynx, lung, colon cancers reported rates time 17.2 months. Patients with shorter than without (29 ± 3.9 versus 67 4.9 months, p: 0.038). Although existing studies conflict each other some points due their design, study 2.5% secondary occurrence rate significantly decreased survival.