Multiple Early Life Stressors as Risk Factors for Neurodevelopmental Abnormalities in the F1 Wistar Rats
نویسندگان
چکیده
Cumulative exposure to multiple early life stressors is expected affect behavioral development, causing increased susceptibility neuropsychiatric disorders. The present study was designed mimic such conditions in a rat model impairments during adolescence and adulthood. Female Wistar rats (n = 32; 140–150 gm) were switched low protein (LP; 8% protein) or control (20% diet 15 days prior conception, then the regime maintained throughout experimental period. Pups born LP dams intraperitoneally injected with deltamethrin (DLT—pyrethroid insecticide; 0.7 mg/kg body weight; PND 1 7), lipopolysaccharide (LPS—bacterial endotoxin; 0.3 3 5), DLT+LPS, on designated forming eight groups (Control, LP, Control+LPS, LP+LPS, Control+DLT, LP+DLT, Control+DLT+LPS LP+DLT+LPS). Neurobehavioral assessments performed F1 (1, 3, 6 months) by open field, elevated plus maze, light dark box, rotarod tests. found be highly susceptible either singular cumulative as compared their age-matched counterparts, showing significantly severe abnormalities, hyperactivity, attention deficits anxiety, hallmark symptoms of disorders like schizophrenia ADHD, suggesting thereby that multi-hit may predispose individuals developmental
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ژورنال
عنوان ژورنال: Brain Sciences
سال: 2023
ISSN: ['2076-3425']
DOI: https://doi.org/10.3390/brainsci13101360