Multimodal targeted high relaxivity thermosensitive liposome for in vivo imaging
نویسندگان
چکیده
منابع مشابه
Multimodal targeted high relaxivity thermosensitive liposome for in vivo imaging
Liposomes are spherical, self-closed structures formed by lipid bilayers that can encapsulate drugs and/or imaging agents in their hydrophilic core or within their membrane moiety, making them suitable delivery vehicles. We have synthesized a new liposome containing gadolinium-DOTA lipid bilayer, as a targeting multimodal molecular imaging agent for magnetic resonance and optical imaging. We sh...
متن کاملNear infrared-fluorescent and magnetic resonance imaging molecular probe with high T1 relaxivity for in vivo multimodal imaging.
A new gadolinium chelating NIR fluorescent molecular probe increases T(1) relaxivity of water protons, facilitating combined optical and magnetic resonance imaging.
متن کاملNear infrared-fluorescent and magnetic resonance imaging molecular probe with high T1 relaxivity for in vivo multimodal imagingw
Integration of optical and magnetic resonance imaging (MRI) methods in one setting is appealing due to the complementary nature of MRI’s high spatial and temporal resolution and the high molecular sensitivity of optical imaging. In particular, deep tissue penetration of near-infrared (NIR) photons and minimal autofluorescence in this wavelength range favors the assessment of molecular events in...
متن کاملMultimodal Molecular Imaging In Vivo
In medical research and practice, imaging is now playing a crucial role. With rapidly developing molecular imaging, the role of in vivo imaging is expected to expand much more. In molecular imaging, one of the recent trends is multimodal imaging, which theoretically combines all the strengths of each imaging modality and consequently provides synergism. For this, many multimodal imaging probes ...
متن کاملPhosphatidylserine-targeted liposome for enhanced glioma-selective imaging
Phosphatidylserine (PS), which is normally intracellular, becomes exposed on the outer surface of viable endothelial cells (ECs) of tumor vasculature. Utilizing a PS-targeting antibody, we have recently established a PS-targeted liposomal (PS-L) nanoplatform that has demonstrated to be highly tumor-selective. Because of the vascular lumen-exposed PS that is immediately accessible without a need...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep17220