Multidrug Resistance Reversal Activity of Taxoids fromTaxus cuspidatein KB-C2 and 2780AD Cells
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چکیده
منابع مشابه
Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K.
A newly synthesized taxoid originally from the Japanese yew Taxus cuspidata, 5-O-benzoylated taxinine K (BTK) was examined for its ability to reverse P-glycoprotein (P-gp) and multidrug resistance protein (MRP)-mediated multidrug resistance. BTK reversed the resistance to paclitaxel, doxorubicin (ADM), and vincristine (VCR) of KB-8-5 and KB-C2 cells that overexpress P-gp by directly interacting...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 2000
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.2000.tb00993.x