Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging

Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging.

Hyperpolarized 13C offers high signal-to-noise ratios for imaging metabolic activity in vivo, but care must be taken when designing pulse sequences because the magnetization cannot be recovered once it has decayed. It has a short lifetime, on the order of minutes, and gets used up by each RF excitation. In this paper, we present a new dynamic chemical-shift imaging method that uses specialized ...

Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies.

Hyperpolarized 13C MR spectroscopic imaging can detect not only the uptake of the pre-polarized molecule but also its metabolic products in vivo, thus providing a powerful new method to study cellular metabolism. Imaging the dynamic perfusion and conversion of these metabolites provides additional tissue information but requires methods for efficient hyperpolarization usage and rapid acquisitio...

Parallel Imaging with RASER using Multiband Frequency-modulated Excitation Pulses

Introduction: The recently described RASER sequence is a conceptual novelty in MR imaging [1]. Based on frequency-swept excitation, and timeencoding, RASER is a rapid, pure T2-weighted scheme without signal voids, ghosting and distortion artifacts present in conventional echo-planar imaging (EPI). These properties render it attractive for functional imaging (fMRI). However, in the previous impl...

3D cardiac Chemical Shift Imaging of [1-13C] hyperpolarized acetate and pyruvate in pigs

Background 13C Dynamic Nuclear Polarization (DNP) with rapid dissolution together with Magnetic Resonance Chemical Shift Imaging (CSI) have been used for non-invasive real-time metabolic assessment in cardiac experimental models on a clinical 3T scanner. Here, we report an in vivo comparison of hyperpolarized [1-13C] pyruvate and [1-13C] acetate perfusion and metabolism: a method based on a 3D ...

Echo Planar Spectroscopic Imaging of Hyperpolarized 13C in a Clinical System with Reduced Chemical Shift Artifacts