Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma
نویسندگان
چکیده
منابع مشابه
Safety of a dust mite extract in severe allergic asthma
Methods We selected 3 adult patients with a confirmed diagnosis of severe persistent allergic asthma (ATS criteria for severe asthma) for at least five years. Mean average topical steroid (inhaled) daily dose was above 1000 mcg of fluticasone propionate or 1600 mcg of budesonide. All patients included in the current trial were clinically relevant sensitized to dust mites (Dermatophagoides spp.)...
متن کاملHouse Dust Mite Allergy and Associated Allergen-Specific Immunotherapy in Allergic Asthma
There is an increasing trend in the global prevalence, morbidity, and economic burden associated with asthma in recent decades [1]. The Global Strategy for Asthma Management and Prevention Report [2] defined asthma as a chronic inflammatory disorder of the airways in which many cells and cellular elements are involved. Both host factors (primarily genetic) and environmental factors (primarily a...
متن کاملHouse dust mite sensitivity in childhood asthma.
The clinical features of perennial asthmatic children with a skin or bronchial reaction to the house dust mite (Dermatophagoides pteronyssinus) were compared with those of asthmatic children without mite sensitivity. Mite sensitive asthma was characterised by an early age of onset of symptoms, these being predominantly nocturnal. A history of wheezing precipitated by dust exposure, during vacuu...
متن کاملDust mite-induced asthma in cynomolgus monkeys.
Animal models exhibiting high homology with humans at the genetic and pathophysiological levels will facilitate identification and validation of gene targets underlying asthma. In the present study, a nonhuman primate model of allergic asthma was developed by sensitizing cynomolgus monkeys to dust mite antigen. Sensitization elevated allergen-specific serum IgE and IgG levels, and peripheral bl...
متن کاملP79 - AsthmaVent – effect of mechanical ventilation on asthmacontrol in house dust mite allergic children with asthma
Background House dust mite allergy is a frequent cause of asthma in children. Children with house dust mite allergy and asthma are especially sensitive to physical and chemical agents in the indoor air and as children spend a lot of time indoors, it seems reasonable to believe that improving the indoor environment will lead to an improvement in asthma disease. At present, there is no clear cons...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-45257-1