Multi-allelic exact tests for Hardy-Weinberg equilibrium that account for gender
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چکیده
منابع مشابه
Exact tests for Hardy-Weinberg proportions.
Exact conditional tests are often required to evaluate statistically whether a sample of diploids comes from a population with Hardy-Weinberg proportions or to confirm the accuracy of genotype assignments. This requirement is especially common when the sample includes multiple alleles and sparse data, thus rendering asymptotic methods, such as the common chi(2)-test, unreliable. Such an exact t...
متن کاملA note on exact tests of Hardy-Weinberg equilibrium.
Deviations from Hardy-Weinberg equilibrium (HWE) can indicate inbreeding, population stratification, and even problems in genotyping. In samples of affected individuals, these deviations can also provide evidence for association. Tests of HWE are commonly performed using a simple chi2 goodness-of-fit test. We show that this chi2 test can have inflated type I error rates, even in relatively larg...
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متن کاملThe mid p-value in exact tests for Hardy-Weinberg equilibrium.
OBJECTIVE Exact tests for Hardy-Weinberg equilibrium are widely used in genetic association studies. We evaluate the mid p-value, unknown in the genetics literature, as an alternative for the standard p-value in the exact test. METHOD The type 1 error rate and the power of the exact test are calculated for different sample sizes, significance levels, minor allele counts and degrees of deviati...
متن کاملBayesian methods for examining Hardy-Weinberg equilibrium.
Testing for Hardy-Weinberg equilibrium is ubiquitous and has traditionally been carried out via frequentist approaches. However, the discreteness of the sample space means that uniformity of p-values under the null cannot be assumed, with enumeration of all possible counts, conditional on the minor allele count, offering a computationally expensive way of p-value calibration. In addition, the i...
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ژورنال
عنوان ژورنال: Molecular Ecology Resources
سال: 2018
ISSN: 1755-098X
DOI: 10.1111/1755-0998.12748