Mucosal vaccination promotes clearance of Streptococcus agalactiae vaginal colonization
نویسندگان
چکیده
منابع مشابه
Serine-rich repeat proteins and pili promote Streptococcus agalactiae colonization of the vaginal tract.
Streptococcus agalactiae (group B streptococcus [GBS]) is a Gram-positive bacterium found in the female rectovaginal tract and is capable of producing severe disease in susceptible hosts, including newborns and pregnant women. The vaginal tract is considered a major reservoir for GBS, and maternal vaginal colonization poses a significant risk to the newborn; however, little is known about the s...
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Streptococcus agalactiae and Candida albicans often co-colonize the female genital tract, and under certain conditions induce mucosal inflammation. The role of the interaction between the two organisms in candidal vaginitis is not known. In this study, we found that co-infection with S. agalactiae significantly attenuated the hyphal development of C. albicans, and that EFG1-Hwp1 signal pathway ...
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conclusions performing only culture method led to missed false negative carriers. therefore, it is recommended that both the pcr assay and conventional culture method be routinely performed to detect gbs in pregnant women accurately. pcr diagnosis demonstrated a shorter turnaround time when compared with the time consuming culture method. results the prevalence of gbs in the 203 collected sampl...
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While many virulence factors promoting Streptococcus pyogenes invasive disease have been described, specific streptococcal factors and host properties influencing asymptomatic mucosal carriage remain uncertain. To address the need for a refined model of prolonged S. pyogenes asymptomatic mucosal colonization, we have adapted a preestrogenized murine vaginal colonization model for S. pyogenes. I...
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We reviewed colonization by group B Streptococcus beta-haemolyticus of Lancefield (SGB), or Streptococcus agalactiae, in pregnant women, and the consequences of infection for the mother and newborn infant, including factors that influence the risk for anogenital colonization by SGB. We also examined the methods for diagnosis and prophylaxis of SGB to prevent early-onset invasive neonatal bacter...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2017
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2017.01.029