Mucoadhesive properties of polyacrylates: Structure – Function relationship

The objective of this study was to evaluate and compare the mucoadhesive properties ten commercially available polyacrylates including linear polyacrylic acid 100 450 kDa (PAA 450), with allyl pentaerythritol, sucrose divinyl glycol cross-linked PAAs AP, PAA AS/AP, DG) as well hydrophobically modified C10-30). Swelling behavior, rheological measurements polymer/mucus mixtures, rotating cylinder studies tensile were performed on intestinal, vaginal buccal mucosa. Investigations swelling behavior revealed that higher degree cross-linking alkylation acrylates/C10-30 alkyl acrylate crosspolymers cause a more pronounced following rank order: C10-30 high > medium low AP AS/AP DG very 100. order dynamic viscosity mixtures Rotating showed all tested polymers depended type porcine mucosa simulated biological buffer. experiments various mucosae highest mucoadhesion high, medium. In contrast, weakest attributed low. Within study, different types compared each other facilitating decision-making for formulation scientists when developing oral, or drug delivery systems.