منابع مشابه
Structural organization and classification of the human mucin genes.
The cells of living organisms in contact with the external environment are constantly attacked by different kinds of substances such as micro-organisms, toxins, and pollutants. With evolution, defense mechanisms, such as the secretion of mucus has been developed. Mucins are the main components of mucus. They are synthesized and secreted by specialized cells of the epithelium and in some case, b...
متن کاملCEBPE-Mutant Specific Granule Deficiency Correlates With Aberrant Granule Organization and Substantial Proteome Alterations in Neutrophils
Citation: Serwas NK, Huemer J, Dieckmann R, Mejstrikova E, Garncarz W, Litzman J, Hoeger B, Zapletal O, Janda A, Bennett KL, Kain R, Kerjaschky D and Boztug K (2018) CEBPE-Mutant Specific Granule Deficiency Correlates With Aberrant Granule Organization and Substantial Proteome Alterations in Neutrophils. Front. Immunol. 9:588. doi: 10.3389/fimmu.2018.00588 Nina K. Serwas1,2†‡, Jakob Huemer1,2‡,...
متن کاملCa21 and protein kinase C activation of mucin granule exocytosis in permeabilized SPOC1 cells
Scott, C. E., Lubna H. Abdullah, and C. William Davis. Ca21 and protein kinase C activation of mucin granule exocytosis in permeabilized SPOC1 cells. Am. J. Physiol. 275 (Cell Physiol. 44): C285–C292, 1998.—Mucin secretion by airway goblet cells is under the control of apical P2Y2, phospholipase C-coupled purinergic receptors. In SPOC1 cells, the mobilization of intracellular Ca21 by ionomycin ...
متن کاملMucin granule-associated proteins in human bronchial epithelial cells: the airway goblet cell "granulome"
BACKGROUND Excess mucus in the airways leads to obstruction in diseases such as chronic bronchitis, asthma, and cystic fibrosis. Mucins, the highly glycosolated protein components of mucus, are stored in membrane-bound granules housed in the cytoplasm of airway epithelial "goblet" cells until they are secreted into the airway lumen via an exocytotic process. Precise mechanism(s) of mucin secret...
متن کاملTranscription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells.
BACKGROUND & AIMS The gastric mucosa provides a stringent epithelial barrier and produces acid and enzymes that initiate digestion. In this regenerating tissue, progenitors differentiate continually into 4 principal specialized cell types, yet underlying mechanisms of differentiation are poorly understood. We identified stomach-restricted expression of the forkhead transcription factor FOXQ1. ...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2007
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2006-0291tr