منابع مشابه
Mucin biosynthesis: molecular cloning and expression of bovine lung mucin core 2 N-acetylglucosaminyltransferase cDNA.
A cDNA clone containing a 2,150-bp insert was isolated from a bovine lung lambdagt10 cDNA library by cross-species hybridization using a DNA probe generated by polymerase chain reaction (PCR) employing a human cDNA that encodes mucin core 2 beta6-N-acetylglucosaminyltransferase (hC2TF) as the template. The bovine cDNA (bcDNA) insert was devoid of 220 bp of the 5' portion of the C2TF open readin...
متن کاملBiosynthesis of high molecular weight breast carcinoma associated mucin glycoproteins.
We have studied the biosynthesis of mucin glycoproteins recognized by monoclonal antibody W1 in MCF7 cells. Proteins of Mr 170,000, 185,000, 260,000, and 275,000 were immunoprecipitated from cells pulse-labeled with [3H]threonine and [3H]proline. Evidence suggesting that these proteins were precursors of high molecular weight mucin(s) included: 1) their kinetics of disappearance corresponded wi...
متن کاملMucin biosynthesis and secretion in the respiratory tract.
s, p. 79.51. Ellis, D. B. Synthesis and secretion of respiratory tract mucin by tracheal explants. Mod. Probl. Paediat. 19: 110-119 (1976).52. Butcher, F. R., and Putney, J. W, Jr. Regulation of parotid gland function by cyclic nucleotides and calcium. Adv. Cyclic Nucl. Res.13: 215-249 (1980). 53.Schulz, I., and Stolze, H. H. The exocrine pancreas: the role ofsecretagogues, ...
متن کاملBiosynthesis of the polymeric gel-forming mucin MUC5B
MUC5B is a major polymeric mucin in the airway mucus gel and is an essential component of innate defense of the respiratory epithelium. Knowledge of the synthesis and intracellular processing of MUC5B is incomplete. We investigated the molecular details of MUC5B assembly in primary human bronchial epithelial cells (HBECs) grown at an air-liquid interface (ALI). Electrophoretic and centrifugal s...
متن کاملGlycoconjugate Biosynthesis Biosynthesis and functions of 0-glycans and regulation of mucin antigen expression in cancer
Secreted mucins and cell-surface mucin-type common 0-glycan core structures can be syntheglycoproteins are rich in 0-glycans and are often sized (Figure 1). Core 1 is the precursor strucresponsible for the expression of biologically ture for the synthesis of core 2, and core 3 is the important ligands and cancer-associated epiprecursor for core 4 [2]. All four common core topes. These epitopes ...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2007
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2006-0334oc