mTORC1 Overactivation Leads to Abnormalities in Skeletal Development
نویسندگان
چکیده
منابع مشابه
Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities.
Npt2 encodes a renal-specific, brush-border membrane Na+-phosphate (Pi) cotransporter that is expressed in the proximal tubule where the bulk of filtered Pi is reabsorbed. Mice deficient in the Npt2 gene were generated by targeted mutagenesis to define the role of Npt2 in the overall maintenance of Pi homeostasis, determine its impact on skeletal development, and clarify its relationship to aut...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2020
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b20-00619