mTORC 1‐ PGC 1 axis regulates mitochondrial remodeling during reprogramming

MiR-31/SDHA Axis Regulates Reprogramming Efficiency through Mitochondrial Metabolism

Metabolism is remodeled when somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs), but the majority of iPSCs are not fully reprogrammed. In a shift essential for reprogramming, iPSCs use less mitochondrial respiration but increased anaerobic glycolysis for bioenergetics. We found that microRNA 31 (miR-31) suppressed succinate dehydrogenase complex subunit A (SDHA) expressi...

NO regulates PGC - 1 α expression 1 Nitric oxide regulates both positively and negatively the mitochondrial oxidative stress protective system through the transcriptional coactivator PGC - 1 α

Dysfunction of the PGC - 1 α / Mitochondria Axis Confers Adriamycin - Induced 1 Podocyte Injury

A Role for PGC-1 Coactivators in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth

Diabetes and Obesity Research Center, Cardiovascular Pathobiology Program, Sanford-Burnham Medical Research Institute, Orlando, Florida; Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain; Department de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain,CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut...

NHE-1 inhibition improves cardiac mitochondrial function through regulation of mitochondrial biogenesis during postinfarction remodeling.

We have recently demonstrated that mitochondrial respiratory dysfunction and mitochondrial permeability transition pore opening during postinfarction remodeling are prevented by the Na(+)/H(+) exchange-1 (NHE-1)-specific inhibitor EMD-87580 (EMD). One of the mechanisms underlying the beneficial effect of NHE-1 inhibition on mitochondria could result from the drug's ability to regulate transcrip...