mTOR signaling, Tregs and immune modulation
نویسندگان
چکیده
منابع مشابه
CD4+ Tregs and immune control.
Recent years have seen Tregs become a popular subject of immunological research. Abundant experimental data have now confirmed that naturally occurring CD25+CD4+ Tregs in particular play a key role in the maintenance of self tolerance, with their dysfunction leading to severe or even fatal immunopathology. The sphere of influence of Tregs is now known to extend well beyond just the maintenance ...
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Patients deficient in the guanine nucleotide exchange factor DOCK8 have decreased numbers and impaired in vitro function of Tregs and make autoantibodies, but they seldom develop autoimmunity. We show that, similarly, Dock8-/- mice have decreased numbers and impaired in vitro function of Tregs but do not develop autoimmunity. In contrast, mice with selective DOCK8 deficiency in Tregs develop ly...
متن کاملmTOR Signaling.
The scarcity of nutrients/energy interspersed with sporadic periods of abundance means that cells must transition between anabolic and catabolic states. An important protein that has evolved to respond to this need is the target of rapamycin (TOR). TOR is a well-conserved serine/ threonine kinase that plays an important role in the signaling network that controls growth and metabolism in respon...
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Thymically derived Foxp3(+) regulatory T cells (tTregs) constitute a unique T cell lineage that is essential for maintaining immune tolerance to self and immune homeostasis. However, Foxp3 can also be turned on in conventional T cells as a consequence of antigen exposure in the periphery, under both non-inflammatory and inflammatory conditions. These so-called peripheral Tregs (pTregs) particip...
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مبحث تحلیل زمان-فرکانسی سیگنالها یکی از مهمترین زمینه های مورد بررسی پژوهشگران علوم ÷ایه کاربردی و فنی مهندسی میباشد.در این پایان نامه فضاهای مدولاسیون به عنوان زمینه اصلی این بررسی ها معرفی گردیده اند و نتایج جدیدی که در حوزه های مختلف ریاضی،فیزیک و مهندسی کاربرداساسی و فراوانی دارند استوار و بیان شده اند.به ویژه در این پایان نامه به بررسی و یافتن مقادیر ویژه عملگر های شبه دیفرانسیل با سمبل در...
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ژورنال
عنوان ژورنال: Immunotherapy
سال: 2014
ISSN: 1750-743X,1750-7448
DOI: 10.2217/imt.14.84