MTHFR Genetic Polymorphism As a Risk Factor in Egyptian Mothers with Down Syndrome Children
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چکیده
منابع مشابه
MTHFR Genetic Polymorphism As a Risk Factor in Egyptian Mothers with Down Syndrome Children
Recent reports linking Down syndrome (DS) to maternal polymorphisms at the methylenetetrahydrofolate reductase (MTHFR) gene locus have generated great interest among investigators in the field. The present study aimed at evaluation of MTHFR 677C/T and 1298A/C polymorphisms in the MTHFR gene as maternal risk factors for DS. Forty two mothers of proven DS outcomes and forty eight control mothers ...
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Recent studies have evaluated possible links between polymorphisms in maternal folate metabolism genes and Down syndrome. Some of these studies show a significantly increased prevalence of the C677T polymorphism of the 5,10-methylene tetrahydrofolate reductase (NADPH) gene (MTHFR) among mothers who have had babies with Down syndrome. This study examined the prevalence of the MTHFR C677T polymor...
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Objective: This study aimed to evaluate the quality of life and related factors in mothers of children with Down syndrome. Methods: The study method was correlation-survey (sectional). Sampling was based on the available population. The research population consisted of all mothers of children with Down syndrome referred to the Down Syndrome Center: out of them 70 mothers of chil...
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OBJECTIVE To assess homocysteine, folic acid and vitamin B12, trace element levels and oxidant/antioxidant status in Down syndrome (DS) mothers and children. DESIGN AND METHODS 42 mothers with previous history of bearing DS baby with karyotypically confirmed full trisomy 21 were included. 48 healthy mothers with their healthy children were considered as control. Serum B12, folic acid, total h...
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ژورنال
عنوان ژورنال: Disease Markers
سال: 2008
ISSN: 0278-0240,1875-8630
DOI: 10.1155/2008/214027