MTE12.01 Clinically Relevant Signal Transduction Pathways

Engineering Signal Transduction Pathways

Cells respond to their environment by sensing signals and translating them into changes in gene expression. In recent years, synthetic networks have been designed in both prokaryotic and eukaryotic systems to create new functionalities and for specific applications. In this review, we discuss the challenges associated with engineering signal transduction pathways. Furthermore, we address advant...

Signal Transduction Pathways for Leptin

Leptin is a critical regulator of energy balance in mammals and has served as a launch point for innumerable studies examining the regulation of food intake and energy expenditure (1). At high physiological concentrations, leptin causes a decrease in food intake, an increase in energy expenditure, and a shift to increased fatty acid oxidation. These physiological shifts lead to a decrease in bo...

Simulation of signal transduction pathways

Signal transduction is about how molecular mechanisms in cells are used to receive, process and respond to signals from outside and inside of the cell. The term signal is defined in a dual way in this context: being the molecular state of a molecule, e.g. a protein, and at the same time an abstract logical state (active/inactive). This thesis focuses on intracellular signalling: i.e. receiving ...

Modelling of Signal Transduction Pathways

This review focusses on modelling of signal transduction pathways. It will introduce the general concepts of modelling and signal transduction, and then proceed with presenting the two most common approaches: Ordinary Di erential Equations (ODE) and Petri Nets (PN). Including an overview about some of the PN upgrades, such as Timed or Coloured Petri Nets, this review will show the major di eren...

Signal transduction pathways regulating hematopoietic differentiation.