MSCs-engineered biomimetic PMAA nanomedicines for multiple bioimaging-guided and photothermal-enhanced radiotherapy of NSCLC

Abstract Background The recently developed biomimetic strategy is one of the mostly effective strategies for improving theranostic efficacy diverse nanomedicines, because nanoparticles coated with cell membranes can disguise as “self”, evade surveillance immune system, and accumulate to tumor sites actively. Results Herein, we utilized mesenchymal stem memabranes (MSCs) coat polymethacrylic acid (PMAA) loaded Fe(III) cypate—an derivative indocyanine green fabricate Cyp-PMAA-Fe@MSCs, which featured high stability, desirable tumor-accumulation intriguing photothermal conversion efficiency both in vitro vivo treatment lung cancer. After intravenous administration Cyp-PMAA-Fe@MSCs Cyp-PMAA-Fe@RBCs (RBCs, red blood membranes) separately into tumor-bearing mice, fluorescence signal MSCs group was 21% stronger than that RBCs at an imaging system. Correspondingly, T 1 -weighted magnetic resonance (MRI) site decreased 30% after injection Cyp-PMAA-Fe@MSCs. Importantly, constructed exhibited strong hyperthermia effect when exposed 808 nm laser irradiation, thus it could be used therapy. Furthermore, tumors on mice treated phototermal therapy radiotherapy shrank 32% more those only radiotherapy. Conclusions These results proved realize fluorescence/MRI bimodal imaging, while phototermal-therapy-enhanced radiotherapy, providing nanoplatforms diagnosis precise non-small