Ms. Crow responds to Ms. Thomson’s comments

Auditory cortex responds in 100 ms to incongruity of melody.

In order to find the cortical neural activities that reflect musical processing, we conducted measurements of MEG responses while subjects listened to familiar melodies. Significant enlargement of the N1m peak was observed in the response to the endnote of a phrase that was deviated to out-of-key from the keynote. Equivalent current sources of the enlarged N1m response were localized in the cor...

Chemical Analysis of Pesticides Using GC/MS, GC/MS/MS, and LC/MS/MS

There are well over 500 registered pesticides worldwide for use in agricultural regions and new agrochemicals are introduced to the marketplace continuously. This chapter deals with the chemical analysis methods for the main pesticide chemical classes that are most frequently analyzed with gas chromatography (GC) or liquid chromatography (LC) coupled to mass spectrometry (MS). GC amenable pesti...

Ms Imaging and Ambient Ionization-ms

Protein identification using MS/MS data.

The subject of this tutorial is protein identification and characterisation by database searching of MS/MS Data. Peptide Mass Fingerprinting is excluded because it is covered in a separate tutorial. Practical aspects of database searching are emphasised, such as choice of sequence database, effect of mass tolerance, and how to identify post-translational modifications. The relationship between ...

HPLC-MS/MS of Highly Polar Compounds