MS-257, a novel sigma receptor ligand: Behavioral pharmacological studies.
نویسندگان
چکیده
منابع مشابه
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متن کاملElectrophysiological, pharmacological and behavioral studies of different physiological roles of the nucleus paragigantocellularis
The nucleus paragigantocellularis (PGI) is located in the rostral ventrolateral medulla and has noticeable connections with some other brain nuclei, such as locus ceruleus, nucleus raphe magnus and periaqueductal gray. In rats it is 3 mm in rostrocaudal and 1 mm in mediolateral and 1 mm in the dorsolateral aspect. Anatomically and functionally, PGI has been divided into two subnuclei, retrofaci...
متن کاملNS-257, a novel competitive AMPA receptor antagonist, interacts with kainate and NMDA receptors.
In this study, we examined the effects of a novel, water-soluble, putative competitive AMPA receptor antagonist, 1,2,3,6,7, 8-hexahydro-3-(hydroxyimino)-N,N,7-trimethyl-2-oxobenzo[2,1- b:3, 4-c']dipyrrole-5-sulfonamide (NS-257) on AMPA, kainate and NMDA receptors using the two-electrode voltage-clamp technique in Xenopus oocytes. All glutamate receptor subtypes were inhibited by NS-257 in a vol...
متن کاملElectrophysiological, pharmacological and behavioral studies of different physiological roles of the nucleus paragigantocellularis
The nucleus paragigantocellularis (PGI) is located in the rostral ventrolateral medulla and has noticeable connections with some other brain nuclei, such as locus ceruleus, nucleus raphe magnus and periaqueductal gray. In rats it is 3 mm in rostrocaudal and 1 mm in mediolateral and 1 mm in the dorsolateral aspect. Anatomically and functionally, PGI has been divided into two subnuclei, retrofaci...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1996
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)36947-1