MR contrast agents in acute experimental cerebral ischemia: Potential adverse impacts on neurologic outcome and infarction size
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چکیده
منابع مشابه
Inhibition of Angiotensin-Converting Enzyme Reduces Cerebral Infarction Size in Experimental-Induced Focal Cerebral Ischemia in the Rat
Background: The role of Renin Angiotensin System (RAS) in ischemic/reperfusion (I/R) injuries is not fully elucidated. Furthermore, it is not clear whether inhibition of RAS by Angiotensin-Converting Enzyme (ACE) inhibitors has beneficial effects in terms of protecting the brain from I/R injuries. In this study enalapril is used as an ACE inhibitor to evaluate the role of RAS in I/R injuries in...
متن کاملAcute cerebral ischemia: CT and MR findings.
It has been reported in two recent papers (1, 2) that magnetic resonance (MR) imaging is more sensitive than computed tomography (CT) in the detection of acute cerebral ischemia. We believe this is not entirely true, at least concerning the early phase of ischemic stroke (within 4 hours from the onset of symptoms). It is our conviction that the earlier the recognition of initial parenchymal inj...
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We investigated the effects of the angiotensin-converting enzyme inhibitor captopril on neurologic outcome in a rat model of incomplete cerebral ischemia. Twenty male Sprague-Dawley rats were anesthetized with 70% nitrous oxide in oxygen and fentanyl (10 micrograms x kg-1 i.v. bolus, 25 micrograms x kg-1 x hr-1 i.v. continuous infusion). Animals in group 1 (n = 10) received no angiotensin-conve...
متن کاملinhibition of angiotensin-converting enzyme reduces cerebral infarction size in experimental-induced focal cerebral ischemia in the rat
background: the role of renin angiotensin system (ras) in ischemic/reperfusion (i/r) injuries is not fully elucidated. furthermore, it is not clear whether inhibition of ras by angiotensin-converting enzyme (ace) inhibitors has beneficial effects in terms of protecting the brain from i/r injuries. in this study enalapril is used as an ace inhibitor to evaluate the role of ras in i/r injuries in...
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Two new potential magnetic resonance imaging contrast agents, Gd-hematoporphyrin (Gd-H) and Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd TCP), were synthesized and applied to nude mice with human melanoma (MM 138) xenografts. These agents showed a high relaxivity because of their greater potential to coordinate water molecules. The reduction of T1 relaxation times of 16 and 21% was observed i...
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ژورنال
عنوان ژورنال: Journal of Magnetic Resonance Imaging
سال: 2000
ISSN: 1053-1807,1522-2586
DOI: 10.1002/(sici)1522-2586(200004)11:4<418::aid-jmri10>3.0.co;2-w