“MPNST Epigenetics”—Response
نویسندگان
چکیده
منابع مشابه
Malignant Peripheral Nerve Sheath Tumors (MPNST)
INTRODUCTION Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas which originate from peripheral nerves or from cells associated with the nerve sheath, such as Schwann cells, perineural cells, or fibroblasts. Because MPNSTs can arise from multiple cell types, the overall appearance can vary greatly from one case to the next. This can make diagnosis and classification somewhat difficu...
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BACKGROUND Malignant peripheral nerve sheath tumors (MPNST) constitute a heterogeneous group of malignant tumors that probably arise from cells of the peripheral nerve sheath. Association of MPNST with neurofibromatosis type 1 (NF1) is frequently reported. MPNST contribute significantly to the reduced life-span of NF1-patients. At present there are only sparse data on MPNST in NF1-children. The...
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Background peripheral nerve sheath tumors comprise a broad spectrum of neoplasms. Vestibular schwannomas and plexiform neurofibromas are symptomatic albeit benign, but a subset of the latter pre-malignant lesions will transform to malignant peripheral nerve sheath tumors (MPNST). Surgery and radiotherapy are the primary strategies to treat these tumors. Intrinsic resistance to drug therapy char...
متن کاملMPNST after Radiosurgery: A Report and Review of the Literature.
OBJECTIVE To report an unusual case of malignant degeneration in a ganglioneuroma of the jugular foramen post stereotactic radiosurgery as well as to systematically review the pertinent literature involving radiosurgery associated malignancies. BACKGROUND Ganglioneuromas are uncommon lesions of the peripheral nervous system and infrequently reported in the head and neck region. There have bee...
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INTRODUCTION HDAC isoform-specific inhibitors may improve the therapeutic window while limiting toxicities. Developing inhibitors against class I isoforms poses difficulties as they share high homology among their catalytic sites; however, HDAC8 is structurally unique compared to other class I isoforms. HDAC8 inhibitors are novel compounds and have affinity for class I HDAC isoforms demonstrati...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2019
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-19-0788