mPGES-1 deletion impairs aldosterone escape and enhances sodium appetite
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منابع مشابه
mPGES-1 deletion impairs aldosterone escape and enhances sodium appetite.
Aldosterone (Aldo) is a major sodium-retaining hormone that reduces renal sodium excretion and also stimulates sodium appetite. In the face of excess Aldo, the sodium-retaining action of this steroid is overridden by an adaptive regulatory mechanism, a phenomenon termed Aldo escape. The underlying mechanism of this phenomenon is not well defined but appeared to involve a number of natriuretic f...
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The synergy between ANG II and aldosterone (Aldo) in the induction of salt appetite, extensively studied in rats, has been tested in baboons. ANG II was infused intracerebroventricularly at 0.5 or 1.0 microg/h; Aldo was infused subcutaneously at 20 microg/h. Separate infusions over 7 days had no significant effect on the daily intake of 300 mM NaCl. Concurrent infusions, however, increased dail...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2010
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.90702.2008