MP84-06 SONIC HEDGEHOG SIGNALING IN CORPORA CAVERNOSAL CELLS FROM DIABETIC, PROSTATECTOMY, HYPERTENSION AND PEYRONIES PATIENTS WITH ED.
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چکیده
منابع مشابه
Sonic Hedgehog Protein Is Decreased and Penile Morphology Is Altered in Prostatectomy and Diabetic Patients
Erectile dysfunction (ED) is a debilitating medical condition and current treatments are ineffective in patients with cavernous nerve (CN) injury, due to penile remodeling and apoptosis. A critical regulator of penile smooth muscle and apoptosis is the secreted protein sonic hedgehog (SHH). SHH protein is decreased in rat prostatectomy and diabetic ED models, SHH inhibition in the penis induces...
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The gene encoding the secreted protein Sonic hedgehog (Shh) is expressed in the polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the posterior margin of the vertebrate limb bud. Detailed analyses have revealed that Shh has the properties of the long sought after polarizing region morphogen that specifies positional values across the antero-posterior axis ...
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ژورنال
عنوان ژورنال: Journal of Urology
سال: 2020
ISSN: 0022-5347,1527-3792
DOI: 10.1097/ju.0000000000000976.06