MP73-12 HISTOPATHOLOGIC FINDINGS AND SURVIVAL CHARACTERISTICS FOR POST-CHEMOTHERAPY ORCHIECTOMY IN ADVANCED GERM CELL CANCER

High-dose chemotherapy plus stem cell transplantation in advanced germ cell cancer: a review.

CONTEXT High-dose chemotherapy (HDCT) with stem cell transplantation (SCT) has been investigated as a treatment strategy for advanced germ cell cancer (GCC) for >2 decades. In an effort to improve on the overall cure rates of 80% achievable with conventional chemotherapy, researchers have investigated this therapeutic option as a first-line therapy for those with poor-prognosis disease and as a...

Sperm integrity pre- and post-chemotherapy in men with testicular germ cell cancer.

BACKGROUND While (partial) recovery of spermatogenesis, observed by means of standard semen analysis, has been seen in testicular cancer patients after chemotherapy with cisplatin, sperm genomic integrity and its implication for the patient's fertility are poorly understood. METHODS Semen and serum from 22 patients treated for testicular cancer were analysed pre- and post-chemotherapy. Beside...

Is orchiectomy always necessary in retroperitoneal extragonadal germ cell tumours?

Relationship between platinum-DNA adducts in leukocytes of patients with advanced germ cell cancer and survival.

Platinum-DNA adducts can be measured in peripheral blood leukocytes during platinum-based chemotherapy, and high adduct levels have been correlated with favorable clinical response in patients with germ cell cancer. Twenty-five patients with advanced germ cell cancer were treated with platinum-based chemotherapy regimens using the same dose and schedule of cisplatin. Platinum-DNA adducts were m...

Intensified neoadjuvant radio-chemotherapy for locally advanced rectal cancer: mono-istitutional experience and long-term results

Background: Purpose: The purpose of our study is to demonstrate that intensified neoadjuvant chemo-radiotherapy (CRT) treatment in locally advanced rectal cancer (LARC), aimed at further enhancing the complete pathological response and local disease control, is feasible and well tolerated.  Materials and Methods: From January 2011 to December 2015, 62 patients (women 21, men 41, mean age 61,5, ...