MP577DIFFERENCES BETWEEN CALCIFEDIOL AND PARICALCITOL ON SOLUBLE KLOTHO LEVELS IN HAEMODIALYSIS PATIENTS
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چکیده
منابع مشابه
Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients
Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form. Soluble Klotho is also generated from alternative splicing of the Klotho gene. In mice, defects in Klotho expression lead to complex phenotypes resembling those observed in dialysis patie...
متن کاملParicalcitol Versus Calcifediol for Treating Hyperparathyroidism in Kidney Transplant Recipients
Introduction Secondary hyperparathyroidism (SHPT) and vitamin D deficiency are common at kidney transplantation and are associated with some early and late complications. This study was designed to evaluate whether paricalcitol was more effective than nutritional vitamin D for controlling SHPT in de novo kidney allograft recipients. Methods This was a 6-month, investigator-initiated, multicen...
متن کاملSoluble α-Klotho serum levels in Chronic Kidney Disease (CKD)
Transmembrane α-Klotho (TM-Klotho), mainly expressed in renal distal tubules, is a co-factor for FGF23 receptor. Circulating soluble α-Klotho (s-Klotho) results from shedding of the ecto-domain of TM-Klotho and has specific effects on urinary Phosphate (P) and Calcium (Ca) transport. The possibility exists that a decrease in TM-Klotho, described in experimental chronic kidney disease (CKD), may...
متن کاملSoluble α-Klotho Serum Levels in Chronic Kidney Disease
Transmembrane α-Klotho (TM-Klotho), expressed in renal tubules, is a cofactor for FGF23-receptor. Circulating soluble-α-Klotho (s-Klotho) results from TM-Klotho shedding and acts on Phosphate (P) and Calcium (Ca) tubular transport. Decreased TM-Klotho, described in experimental chronic kidney disease (CKD), prevents actions of FGF23 and lessens circulating s-Klotho. Thus, levels of s-Klotho cou...
متن کاملEstablishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects.
BACKGROUND Alpha-Klotho (alphaKl) regulates mineral metabolism such as calcium ion (Ca(2+)) and inorganic phosphate (Pi) in circulation. Defects in mice result in clinical features resembling disorders found in human aging. Although the importance of transmembrane-type alphaKl has been demonstrated, less is known regarding the physiological importance of soluble-type alphaKl (salphaKl) in circu...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2016
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/gfw197.12