MP35-18 EXTRACORPOREAL SHOCKWAVE THERAPY IMPROVES CP/CPPS BY DOWN-REGULATING NLPR3 INFLAMMASOME IN A PROSTATITIS RAT MODEL

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease the Genitourinary Tract: Prostate & Genitalia (MP35)1 Sep 2021MP35-18 EXTRACORPOREAL SHOCKWAVE THERAPY IMPROVES CP/CPPS BY DOWN-REGULATING NLPR3 INFLAMMASOME IN A PROSTATITIS RAT MODEL Dongho Shin, Yong Hyun Park, Hyuk Jin Cho, Usyn Ha, Sunghoo Hong, Ji Youl Lee, Sae Woong Kim, Sang Hoon Byung Il Yoon, and Bae ShinDongho Shin More articles by this author , ParkYong Park ChoHyuk Cho HaUsyn Ha HongSunghoo Hong LeeJi Lee KimSae Kim KimSang YoonByung Yoon BaeWoong View All Author Informationhttps://doi.org/10.1097/JU.0000000000002044.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The aim study was evaluate anti-inflammatory antioxidative effects extracorporeal shockwave therapy (ESWT) on prostatitis explore mechanism. METHODS: RWPE-1 cells randomly divided into 5 groups: 1 group (normal control), 2 LPS (lipopolysaccharide inducing inflammation), 3 0.1ESWT (treated 0.1mJ/mm2 ESWT), 4 0.2ESWT 0.2mJ/mm2 ESWT) 0.3ESWT 0.3mJ/mm2 ESWT). After ESWT administered, supernatant were collected for ELISA western blot. In vivo, Sprague-Dawley rats (n=36) normal group, (12 each). Prostatitis induced 17 beta-estradiol dihydrotestosterone. weeks after ESWT, pain index assessed all groups prostates immunohistochemistry, immunofluorescence, apoptosis analysis RESULTS: optimal energy flux density 0.2 mJ/mm2 in vitro. ameliorated discomfort with prostatitis. Inflammation improved (P<0.05). Compared rats, overexpressed NLRP3 inflammasomes triggered which TLR4-NFκB pathway overactive prostatitis, compared And BAX/BAK inhibited CONCLUSIONS: reducing inflammasome via inhibiting a rat model. TLR4 might be key protein bonding pathway. should potential promising treatment CP/CPPS. Source Funding: none © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e634-e634 Advertisement Copyright Permissions© Inc.MetricsAuthor Information Expand Loading ...