MP31-03 MICRODISSECTION TESTICULAR SPERM EXTRACTION VS MULTIPLE NEEDLE-PASS PERCUTANEOUS TESTICULAR SPERM ASPIRATION IN MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA: A RANDOMIZED CLINICAL TRIAL

You have accessJournal of UrologyInfertility: Therapy (MP31)1 Sep 2021MP31-03 MICRODISSECTION TESTICULAR SPERM EXTRACTION VS MULTIPLE NEEDLE-PASS PERCUTANEOUS ASPIRATION IN MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA: A RANDOMIZED CLINICAL TRIAL Christian Fuglesang S. Jensen, Dana A. Ohl, Mikkel Fode, Niels Jørgensen, Aleksander Giwercman, Angel Elenkov, Anna Klajnbard, Claus Y. Andersen, Lise Aksglaede, Marie Louise Grøndahl, Mette C. Bekker, and Jens Sønksen JensenChristian Jensen More articles by this author , OhlDana Ohl FodeMikkel Fode JørgensenNiels Jørgensen GiwercmanAleksander Giwercman ElenkovAngel Elenkov KlajnbardAnna Klajnbard AndersenClaus Andersen AksglaedeLise Aksglaede GrøndahlMarie Grøndahl BekkerMette Bekker SønksenJens View All Author Informationhttps://doi.org/10.1097/JU.0000000000002035.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Non-obstructive azoospermia (NOA) is a severe infertility diagnosis. No level-1 evidence supports specific surgical sperm retrieval procedure. Microdissection testicular extraction (mTESE) has gained popularity due reports on relatively high rates (SRR) ranging 30–70%. However, mTESE an invasive, demanding costly We previously reported SRR for modified needle aspiration (TESA) applied in NOA men (Jensen et al. 2016). Modified TESA done with 18-gauge performing multiple passes (50-100) while applying vacuum. The from procedure was 30%. When salvage after unsuccessful TESA, the only 11%. Therefore, we hypothesized that effective alternative mTESE. Accordingly, conducted first randomized clinical trial comparing METHODS: Ethical approval obtained, prospective between 04/2017–10/2020. Inclusion criteria were according WHO, testis volume ≤15ml no indication obstructive causes azoospermia. Exclusion previous or biopsy, anejaculation, retrograde ejaculation, Klinefelter’s Syndrome, XX male, AZFa/b microdeletion CFTR mutation. calculated population size 100 (using 25% 52% mTESE, power 80% alpha 0.05) expected drop-out rate 10%, 110 needed be included. Men TESA. Patients failed proceeded directly operating room. primary outcome successful retrieval. SRRs compared using Chi-square test. Statistical significance set at p<0.05. RESULTS: included, 10 withdrew before randomization underwent surgery. Median age 33 years (range 22–54). Spermatozoa retrieved 11/51 (22%) 21/49 (43%) undergoing (p=0.02). SSR 4/38 (11%). Thus, combined 15/51 (29%) which did not reach statistical (p=0.16). CONCLUSIONS: In direct comparison higher Although powered such comparison, study may indicate combining viable reducing invasiveness cost proportion patients. Source Funding: European Reasearch Council, ReproUnion © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e555-e556 Advertisement Copyright & Permissions© Inc.MetricsAuthor Information Expand Loading ...