MP26-06 EFFECTS OF MAGNETIC RESONANCE IMAGING TARGETING ON OVERDIAGNOSIS AND OVERTREATMENT OF PROSTATE CANCER

You have accessJournal of UrologyProstate Cancer: Detection & Screening II (MP26)1 Sep 2021MP26-06 EFFECTS OF MAGNETIC RESONANCE IMAGING TARGETING ON OVERDIAGNOSIS AND OVERTREATMENT PROSTATE CANCER Andrew Vickers VickersAndrew More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002023.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION OBJECTIVE: It has been suggested that targeting prostate lesions identified on magnetic resonance imaging (MRI) will improve the sensitivity biopsy for high-grade disease. The clinical significance tumors found MRI-targeting in men with benign systematic findings is open question. We compared data from National Cancer Institute (NCI) study MRI-targeted results long-term follow-up who had negative sextant European Randomized trial Prostate (ERSPC) METHODS: NCI included finding 999 biopsy. For ERSPC, 3,056 were followed 11 years. calculated number patients needing be diagnosed (NND) and treated (NNT) following targeted order prevent one cancer death at used a simple modelling approach involved several assumptions, such as proportion deaths ERSPC would prevented earlier diagnosis initial MRI-guided. then varied these assumptions assess effects results. RESULTS: In base scenario, which favorable MRI, NND NNT 89 57 (table). Results only more encouraging under unlikely scenarios, 100% MRI cure rates treatment. CONCLUSIONS: Although may benefit overall, considering decreases overdiagnosis resulting avoidance scans, needles MRI-detected large per prevented. Consideration should given changing guidelines grading cores those regarding treatment cancer. Source Funding: This work was supported part Institutes Health/National (NIH/NCI) Center Support Grant Memorial Sloan Kettering [P30 CA008748], SPORE grant Dr. H. Scher [P50-CA92629], Sidney Kimmel Urologic Cancers David Koch through Foundation. © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e464-e464 Advertisement Copyright Permissions© Inc.MetricsAuthor Information Expand Loading ...