منابع مشابه
Mouse Models for Type 1 Diabetes.
Our understanding of the genetics, aetiology and pathogenesis of Type 1 Diabetes (T1D) was propelled by the discovery of animal models of T1D in the late 1970s and early 1980s, particularly the non-obese diabetic (NOD) mouse. Since then, transgenic and gene-targeting technologies allowed the generation of many models with reduced genetic and pathogenic complexity. These models allowed researche...
متن کاملIncreased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes.
As the population of the United States ages, the incidence of age-related neurodegenerative and systemic diseases including Alzheimer's disease (AD) and diabetes is increasing rapidly. Multiple studies report that patients with diabetes have a 50-75% increased risk of developing AD compared with age- and gender-matched patients without diabetes. Abnormally phosphorylated tau is a major building...
متن کاملDevelopment of the Nonobese Diabetic Mouse and Contribution of Animal Models for Understanding Type 1 Diabetes
In 1974, the discovery of a mouse and a rat that spontaneously developed hyperglycemia led to the development of 2 autoimmune diabetes models: nonobese diabetic (NOD) mouse and Bio-Breeding rat. These models have contributed to our understanding of autoimmune diabetes, provided tools to dissect autoimmune islet damage, and facilitated development of early detection, prevention, and treatment of...
متن کاملDeficiencies of cardiovascular risk prediction models for type 1 diabetes.
OBJECTIVE Cardiovascular risk prediction models are available for the general population (Framingham) and for type 2 diabetes (U.K. Prospective Diabetes Study [UKPDS] Risk Engine) but may not be appropriate in type 1 diabetes, as risk factors including younger age at diabetes onset and presence of diabetes complications are not considered. Therefore, our objective was to examine the accuracy of...
متن کاملInsulin Metabolism Models for Children with Type 1 Diabetes
IntroductIon Diabetes Mellitus (DM) is a chronic metabolic disease resulted from insufficient secretion of hormone insulin. DM is mainly classified into Type 1 (or insulin dependent diabetes), which is characterized by absence of insulin secretion, due to destruction of the β-cells of pancreas, and Type 2 (or insulin independent diabetes), which is characterized by reduced action of insulin. Th...
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ژورنال
عنوان ژورنال: Drug Discovery Today: Disease Models
سال: 2009
ISSN: 1740-6757
DOI: 10.1016/j.ddmod.2009.03.008