Mouse Experimental Myopia Has Features of Primate Myopia

Form deprivation modulates retinal neurogenesis in primate experimental myopia.

Juvenile primates develop myopia when their visual experience is degraded by lid fusion. In response to this abnormal visual input, retinal neural networks cause an excessive growth of the postequatorial segment of the eye, but the mechanism underlying this axial elongation is unknown. After fusion of the lids in one eye of juvenile rhesus macaques and green monkeys, we combined cDNA subtractio...

Experimental Myopia in Chicks

more frequently in the spring and the fall, and a relationship to temperature or to changes in temperature may be involved (unpublished observations, Kaufman HE, 1981; Barren BA, 1994). The appearance of fever blisters and clinical herpes during temperature stress in hudans is a well-known clinical phenomenon. Our primate model may provide a way to study this relationship in a laboratory settin...

Experimental myopia in rabbits.

About 1 diopter (D) myopic change was induced experimentally in rabbit eyes by raising the body temperature and increasing the intraocular pressure with a specially designed suction cup. The myopic changes only took place when the body temperature was 41 to 43° C, intraocular pressure was above 40 mm. Hg, and topical atropine was given. Eyes subjected to repeated high pressure after the initial...

Two models of experimental myopia in the mouse

PURPOSE The purpose of this study was to test the response of the mouse eye to two methods for the induction of experimental myopia. METHODS Growth patterns of eyes were determined by axial length measurements from birth to adult in eyes of both sexes of normal mice examined on post-natal day 1 to 6 months and at 1 year. For the induction of experimental myopia, Balb/cJ mice were prepared wit...

Myopia.