Mouse-Derived Isograft (MDI) In Vivo Tumor Models I. Spontaneous sMDI Models: Characterization and Cancer Therapeutic Approaches

I-54: New Models for Human and Mouse Genetic

The possibility to reprogram somatic human cells will greatly and deeply change genetic approach and allow the development of new tools to study genetics diseases. Indeed, our ability to study human genetic diseases suffers from the lack of valid in vitro models. The latter should (i) be originating from human primary cells, (ii) be able to self-renew for a long time and (iii) be able to differ...

Mouse Models of Colorectal Cancer-Derived Circulating Tumor Cells

Metastasis is the major cause of death in colorectal cancer (CRC) patients. Circulating tumor cells (CTCs) are the biologic correlate of metastasis. Despite the clinical relevance of CTCs, there has been little progress in understanding their biology in detail; particularly the phenotype of CTCs with metastasis-forming capacities is still unknown. In this article we discuss the benefits and lim...

Therapeutic Discovery HDL Mimetics Inhibit Tumor Development in Both Induced and Spontaneous Mouse Models of Colon Cancer

Recent studies suggest that high-density lipoprotein (HDL) levels are inversely related to colon cancer risk. HDL mimetics constructed from a number of peptides and proteins with varying structures possess anti-inflammatory and antioxidant properties reminiscent of HDL. In this article, we examined whether HDLmimetics, L-4F (an apolipoprotein A-I mimetic peptide) and G (an apolipoprotein J mime...

HDL mimetics inhibit tumor development in both induced and spontaneous mouse models of colon cancer.

Recent studies suggest that high-density lipoprotein (HDL) levels are inversely related to colon cancer risk. HDL mimetics constructed from a number of peptides and proteins with varying structures possess anti-inflammatory and antioxidant properties reminiscent of HDL. In this article, we examined whether HDL mimetics, L-4F (an apolipoprotein A-I mimetic peptide) and G* (an apolipoprotein J mi...

Derived Tumor Xenografts : transforming clinical samples into mouse models