Mouse Chromosome 11
نویسندگان
چکیده
منابع مشابه
Clustering of cytokine genes on mouse chromosome 11
The presence of positionally conserved amino acid residues suggests that the mouse proteins TCA3, P500, MIP1-alpha, MIP1-beta, and JE are members of a single gene family. These proteins are activation specific and can be expressed by both myeloid and lymphoid cells. MIP1-alpha/MIP1-beta and MCAF (the putative human homologue of JE) act as chemotactic and activating agents for neutrophils and ma...
متن کاملMouse galactokinase: isolation, characterization, and location on chromosome 11.
Elevated galactose levels can be caused by several enzyme defects, one of which is galactokinase. Galactokinase deficiency cause congenital cataracts during infancy and presenile cataracts in the adult population. We have isolated the mouse cDNA for galactokinase, which shares extensive amino acid sequence homology, 88% identity, with a recently cloned human galactokinase. It is expressed in al...
متن کاملChanges in Nuclear Orientation Patterns of Chromosome 11 during Mouse Plasmacytoma Development1
Studying changes in nuclear architecture is a unique approach toward the understanding of nuclear remodeling during tumor development. One aspect of nuclear architecture is the orientation of chromosomes in the three-dimensional nuclear space. We studied mouse chromosome 11 in lymphocytes of [T38HxBALB/c]N mice with a reciprocal translocation between chromosome X and 11 (T38HT(X;11)) exhibiting...
متن کاملLocalization of the panhypopituitary dwarf mutation (df) on mouse chromosome 11 in an intersubspecific backcross.
Ames dwarf (df) is an autosomal recessive mutation characterized by severe dwarfism and infertility. This mutation provides a mouse model for panhypopituitarism. The dwarf phenotype results from failure in the differentiation of the cells which produce growth hormone, prolactin, and thyroid stimulating hormone. Using the backcross (DF/B-df/df X CASA/Rk) X DF/B-df/df, we confirmed the assignment...
متن کاملIdentification of a genetic locus on chromosome 11 that regulates leukocyte infiltration in mouse carotid artery.
OBJECTIVE We demonstrated that inflammatory cells and intima-media thickening are increased in carotids exposed to low-blood flow in the SJL/J (SJL) strain compared with other mouse strains. We hypothesized that the extent of inflammation associated with intima-media thickening is a genetically regulated trait. APPROACH AND RESULTS We performed a whole genome approach to measure leukocyte inf...
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ژورنال
عنوان ژورنال: Mammalian Genome
سال: 1992
ISSN: 0938-8990,1432-1777
DOI: 10.1007/bf00648429